In T 1-weighted fat-suppressed contrast-enhanced sequences, there were two types of enhancement: homogeneously hyperintense lesions (in 10 of 14 cases) or peripherally hyper-, centrally isointense (in 4 of 14 cases). These lesions were isointense (4 cases) to slightly hyperintense (10 of 14 cases) on T 2-weighted sequences. A focal pancreatic lesion, which was hypointense on T 1-weighted sequences, was detected on all the MR images (14 of 27 patients 100%). Preoperative tumor localization was achieved by means of MRI and CT. Results: The female: male ratio was 2.9, with a mean age of 47.5 years (range 12–82). Pathologic correlation was available for all the lesions. For each lesion, images were analyzed based on the presence of enhancement or the characteristics of signal intensities. Preoperative CT (14 of 27 patients) and MRI studies (14 of 27 patients, one patient had both MRI and CT), operation reports, intraoperative ultrasonography reports, and pathological diagnoses were analyzed retrospectively. Patients and Methods: Between December 2001 and June 2010, 27 consecutive patients with clinically suspected insulinoma were surgically treated in our university hospital. The aims of this study were to localize insulinomas preoperatively using CT and/or MRI in correlation with postoperative pathological results. Purpose: Insulinomas are rare tumors that originate from the islet cells of the pancreas.
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